This Primer is intended to give an introduction to the aspects of OoC that need to be considered when developing an application-specific OoC. There are as many examples of OoCs as there are applications, making it difficult for new researchers to understand what makes one OoC more suited to an application than another. ![]() Combining advances in tissue engineering and microfabrication, OoCs have gained interest as a next-generation experimental platform to investigate human pathophysiology and the effect of therapeutics in the body. ![]() To better mimic human physiology, the chips are designed to control cell microenvironments and maintain tissue-specific functions. ![]() Organs-on-chips (OoCs) are systems containing engineered or natural miniature tissues grown inside microfluidic chips.
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